The atypical protein kinase C inAplysiacan form a protein kinase M by cleavage
نویسندگان
چکیده
منابع مشابه
The atypical protein kinase Cs
Since its discovery more than 10 years ago, the atypical PKC (aPKC) subfamily has attracted great interest. A number of reports have shown that the kinases of this subfamily play critical roles in signaling pathways that control cell growth, differentiation and survival. Recently, several investigators have identified a number of aPKC-interacting proteins whose characterization is helping to un...
متن کاملSerotonin-induced cleavage of the atypical protein kinase C Apl III in Aplysia.
A constitutively active kinase, known as protein kinase Mζ (PKMζ), is proposed to act as a long-lasting molecular memory trace. While PKMζ is formed in rodents through translation of a transcript initiating in an intron of the protein kinase Cζ (PKCζ) gene, this transcript does not exist in Aplysia californica despite the fact that inhibitors of PKMζ erase memory in Aplysia in a fashion similar...
متن کاملTargeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms.
Protein kinase C lambda (PKClambda) is an atypical member of the PKC family of serine/threonine kinases with high similarity to the other atypical family member, PKCzeta. This similarity has made it difficult to determine specific roles for the individual atypical isoforms. Both PKClambda and PKCzeta have been implicated in the signal transduction, initiated by mediators of innate immunity, tha...
متن کاملTargeted Deletion of Protein Kinase C Reveals a Distribution of Functions between the Two Atypical Protein Kinase C Isoforms
Protein kinase C (PKC ) is an atypical member of the PKC family of serine/threonine kinases with high similarity to the other atypical family member, PKC . This similarity has made it difficult to determine specific roles for the individual atypical isoforms. Both PKC and PKC have been implicated in the signal transduction, initiated by mediators of innate immunity, that culminates in the activ...
متن کاملCaspase processing activates atypical protein kinase C zeta by relieving autoinhibition and destabilizes the protein.
Treatment of HeLa cells with tumour necrosis factor alpha (TNFalpha) induced caspase processing of ectopic PKC (protein kinase C) zeta, which converted most of the holoenzyme into the freed kinase domain and increased immune-complex kinase activity. The goal of the present study was to determine the basis for the increased kinase activity that is associated with caspase processing of PKC zeta. ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2009
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2009.06045.x